Hyperinsulinemic hypoglycemia is a potentially lethal disease caused by inadequate production of insulin by the beta cells of the pancreatic islets of Langerhans. Lethal hypoglycemia and brain damage is a problem especially in infants born with the disease. The major problem of current therapeutic approaches (partial/near total pancreatectomy combined with medical treatment) are the frequently observed severe side effects/morbidity (diabetes, exocrine pancreas insufficiency etc.) since they massively reduce quality of life as well as life expectancy. However, they are considered acceptable in relation to the lethal or debilitating outcome of the disease itself if left untreated.